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Re: [新聞] Moderna疫苗早期臨床試驗結果有效

看板Stock標題Re: [新聞] Moderna疫苗早期臨床試驗結果有效作者
SnowFerret
(雪貂)
時間推噓66 推:68 噓:2 →:46

※ 引述《Dimitre (迪米崔)》之銘言:
: 1.原文連結:
: ※過長無法點擊者必須縮網址
: https://reurl.cc/GVGreD
: 2.原文內容:
: Moderna’s closely watched early-stage human trial for a coronavirus vaccine: produced Covid-19 antibodies in all 45 participants, the biotech company
: announced Monday.
: Each participant was assigned to receive a 25 microgram, 100 mcg or 250 mcg: dose, with 15 people in each dose group. Study participants received two
: doses of the potential vaccine via intramuscular injection in the upper arm: approximately 28 days apart. Data on a second dose was not available for the: 250 mcg group, the company said.
: At day 43, or two weeks following the second dose, levels of binding
: antibodies in the 25 mcg group were at the levels generally seen in blood
: samples from people who recovered from the disease, the company said.
: Antibodies in the 100 mcg had antibodies that “significantly exceeded levels: ” in recovered patients.
: The vaccine also produced neutralizing antibodies against Covid-19 in at
: least eight participants, the company said. Four participants were assigned: to receive a 25 microgram dose, while the other four received 100 mcg. Levels: of neutralizing antibodies were at or above levels in blood samples, the
: company said. Data on neutralizing antibodies for the other participants were: not yet available, Moderna said.
: “These interim Phase 1 data, while early, demonstrate that vaccination with: mRNA-1273 elicits an immune response of the magnitude caused by natural
: infection starting with a dose as low as 25 μg,” Tal Zaks, the chief
: medical officer at Moderna, said in s statement.
: “When combined with the success in preventing viral replication in the lungs: of a pre-clinical challenge model at a dose that elicited similar levels of: neutralizing antibodies, these data substantiate our belief that mRNA-1273
: has the potential to prevent COVID-19 disease and advance our ability to
: select a dose for pivotal trials,” Zaks added.
: There are formally approved treatments for Covid-19, which has killed at
: least 315,225 and sickened 4.7 million people worldwide since emerging from: the Chinese city of Wuhan more than 4 months ago, according to data compiled: by Johns Hopkins University.
: Moderna has been fast-tracking work with the National Institutes of Health,: an agency within the Department of Health and Human Services, to develop a
: vaccine.
: The company said the vaccine was generally safe and well tolerated.
: The potential vaccine by Moderna contains genetic material called messenger: RNA, or mRNA, that was produced in a lab. The mRNA is a genetic code that
: tells cells what to build — in this case, an antigen that may induce an
: immune response for the virus.
: The phase 1 trial took place at the Kaiser Permanente Washington Health
: Research Institute in Seattle, Washington. It tested the vaccine on 45 males: and non-pregnant females between the ages of 18 and 55.


如果把細菌比喻成敵軍, 抗體就是保護身體的軍隊.

一個正常國家, 只要遭受入侵就會反擊 > 這就是產生抗體.

但是抗體有特異性, 只對某種病毒有效. 拿對付一般感冒的抗體打武漢肺炎是沒有用的

就像是病毒開坦克近來, 我們讓士兵拿50手槍反擊, 叮叮噹噹效果跟BB槍差不多.

應該要找有RPG的抗體過來才對.



回到報導, 這篇報導包含三個訊息

1. 25ug即可引發免疫反應.

這是好消息. 代表只要少量的假想敵就可以讓身體產生軍隊準備抗敵.

2. 100ug劑量產生的的抗體量超過恢復期的量

好消息. 越多假想敵, 身體會製造越多軍隊.

3. 少部分人有副作用, 但無生命危險.

算好消息吧? 至少還不會自己被假想敵幹掉, 尚可接受.

但樣本數低, 擴大接踵後未必不會出現致死.

例如: 流感感冒疫苗還是有案例接踵後致死.


這三點代表這個疫苗是可接受的 (但不代表有效)

但這也並不能說是什麼重大突破, 畢竟疫苗本該就要觸發免疫反應 (促進身體製造軍隊)

如果沒辦法, 那不如注射一罐舒跑好了.



以上是這篇新聞所含的訊息




比較重要的應該是這篇新聞內的一段

這是他們自己公司發的

https://investors.modernatx.com/news-releases/news-release-details/
moderna-announces-positive-interim-phase-1-data-its-mrna-vaccine


At this time, neutralizing antibody data are available only for the first
four participants in each of the 25 μg and 100 μg dose level cohorts.
Consistent with the binding antibody data, mRNA-1273 vaccination elicited
neutralizing antibodies in all eight of these participants, as measured by
plaque reduction neutralization (PRNT) assays against live SARS-CoV-2. The
levels of neutralizing antibodies at day 43 were at or above levels generallyseen in convalescent sera.


4. 8個病人有產生可以對付新冠的抗體.

不過他們的意思好像是只做8個取樣, 25ug的病人 x4 100ug的病人 x4

8位都有產生可以對付新冠的抗體.


看上去是100%啦

但是用這消息來看是否有效言之過早, 因為檢驗有沒有效是更後面的事情,

有更嚴格且更可靠的檢驗.

這邊只能說是偷喵看答案. 先給大家聞一下香味, 真香一下. 炒個股票.



有做過研究的都知道, 實驗數據常常報喜不報憂. 就算內行人也常常被忽悠得團團轉.

現在這個聲明來自於自家公司, 也沒有任何數據或是實驗圖片佐證.

到底這個士兵拿的RPG是真的火箭彈, 還是水火箭.

還是要等到第三階段才知道

目前結果大家聽聽就好, 不要真以為是解藥.


補充: 會叫大家不要相信解藥出來了, 是因為這個聲明說"有效", 可中和病毒.

但這個在實驗中的"有效", 其實是個很大的模糊地帶.

就像雅量課文說的, 有人看像稿紙, 有人看像棋盤, 但對我來說它就是塊綠豆糕.

媽的綠豆糕這也差太多了吧.

但你又不能說我錯, 這是"我的"解讀阿.

所以除非論文發出來, 不然就再看看囉.



不過炒股還是可以炒啦

畢竟大家不在乎真相, 只在乎股價.


--

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※ 編輯: SnowFerret (61.231.49.35 臺灣), 05/18/2020 23:57:13

elfish123 05/18 23:56這樣就已經夠了,ok?

j5163124 05/18 23:57好像有3個出現嚴重副作用,多嚴重沒說

※ 編輯: SnowFerret (61.231.49.35 臺灣), 05/19/2020 00:02:22

cuteSquirrel05/18 23:58好dery

elfish123 05/18 23:58mrna目前漲26% who care 細節

zakijudelo 05/18 23:59j大很像滿怕疫苗股去衝擊到其他防疫股的說XD

braja5566 05/18 23:59沒人在乎 噴就對了

bons2 05/19 00:00今天美股差不多也是這樣了,繼續往上攻的力道不足

bons2 05/19 00:00說不定尾盤還要往下拉一點

tamama000 05/19 00:008個人 =漲停8根

j5163124 05/19 00:02我是不知道你被嘎了幾張空單啦,實話實說而已

AGODC 05/19 00:02講得淺顯易懂給推

TokyoHard 05/19 00:03舒跑可以注射嗎?

※ 編輯: SnowFerret (61.231.49.35 臺灣), 05/19/2020 00:05:19

j5163124 05/19 00:05瑞德西韋還有報告出來,這個什麼東西都沒有

kuluya997 05/19 00:06市場就是找到理由可以嘎 那就尊重市場是對的

SRadiant 05/19 00:06先前國光的新聞也是說疫苗有效(笑)

xcdf 05/19 00:06who car

kyova 05/19 00:06都漲快1000點了,還在上攻力道不足...是太習慣熔斷

amingoliu 05/19 00:07推,雅量,共同記憶

sakula0616 05/19 00:073個有副作用是劑量太高 輕量的十倍 所以這可以忽略

kyova 05/19 00:07噴了嗎... 本來上升段就很容易猶疑而不會一步到位

elfish123 05/19 00:08所以國光漲了啊哈哈

zakijudelo 05/19 00:08明天優先掛高端,其他防疫股就意思意思一下看狀況囉

ceca 05/19 00:08快,到底要買哪一支?

ChangZhu 05/19 00:08all in融資開滿等數錢

nelsonhsiao 05/19 00:08少數人怎麼解讀不重要,股市重點是多數人怎麼想。

f204137 05/19 00:09不要在嚇空軍了

Sinkage 05/19 00:108個人漲8百點 好準

Mradult 05/19 00:11學術討論不重要,股票會噴就好,重點是要來得及上

Mradult 05/19 00:11

a125g 05/19 00:11如果全世界的人都是研究生技的專家 那明天疫苗股

a125g 05/19 00:11漲幅不大

a125g 05/19 00:11但問題是不是

elfish123 05/19 00:12可惜不是

msisee 05/19 00:15想起台灣生技股 先喊先贏 後面的 管他的

GalacticEcho05/19 00:15有這樣的專業分析才好吧。如果疫苗真的有效,你的

GalacticEcho05/19 00:15多單可以放心長抱;如果疫苗離成功還有很遠的距離

GalacticEcho05/19 00:15,你至少比其它狂歡中的散戶知道要早一步下車。

zakijudelo 05/19 00:15原本應該很多人想加入進香團,疫苗消息出來後,或許

zakijudelo 05/19 00:15成為高端份子、國光幫會更熱門XD

msisee 05/19 00:16希望不是從前有一個太監

girld 05/19 00:17葉佩 舒跑 哈哈

KotoriCute 05/19 00:19現在疫苗股都是先喊先贏

a5413eric 05/19 00:20原來是葉佩雯= =

Linvail 05/19 00:22說不定拿的是標槍飛彈呢

sluttervagen05/19 00:24管他的,這種消息就是先漲停3天再說

c7683fh6 05/19 00:27

Merman19 05/19 00:30先炒一波阿

bons2 05/19 00:31對啦,借題發揮漲三天又再掉下來了,沒什麼

tina00018 05/19 00:33嘎慘

teeo 05/19 00:34專業翻譯推

AGODC 05/19 00:34了解是真有用還假有用,你才能比別人搶得先機,要跑

AGODC 05/19 00:34要抱才有底阿,不是?

julian42 05/19 00:34連花王都可以炒作,高端一定噴爆

elfish123 05/19 00:35也不想想上次國光有好消息漲了多久,怎麼可能只漲三

elfish123 05/19 00:35

elfish123 05/19 00:36在三期還沒跑完之前 難道你要一直當無效?

elfish123 05/19 00:36只會一直怎麼可能@% 看著飆上去

rfireptt 05/19 00:40漲停3天也有30%啊

sentiswab 05/19 00:41浩鼎在解盲前也是一直漲

qwer2411 05/19 00:41不懂唱衰的是在高尚啥

bio5chris 05/19 00:42推這篇

OneDianHwen 05/19 00:44有道理!

Loro5241 05/19 00:45舒跑概念股感覺比較穩(誤

pk78512002 05/19 00:47懂~ 買起來

zakijudelo 05/19 00:47唱衰的是怕原先口罩一片光明的美夢被疫苗股搶走風采

zakijudelo 05/19 00:47啊,看上面的po文就知道,嘻嘻

opencat 05/19 00:52本來以為口罩可以爽到年底,結果qq

aneshsiao 05/19 00:53雪貂就是ferret 不用再加snow

danny2451 05/19 00:54口罩真的不要玩 現在大招出口已經開了 再套沒招了

j5163124 05/19 00:58某人不知道被嘎幾張空單,在那邊套人家帽,可憐哪

julian42 05/19 01:00疫苗一炒口罩就不潮了,想像空間差太多

StuLeo 05/19 01:00ˋ結論非常好

danny2451 05/19 01:02口罩應該還是短多吧 但啥時下去就不知道了

danny2451 05/19 01:03至於一堆講得好像疫苗量產的就乖乖炒吧 祝賺錢

safah 05/19 01:07...根本就只是出來放消息炒股的 樣本數少到可憐 我

safah 05/19 01:07看是選擇過的吧

elfish123 05/19 01:08沒關係啦,大家還是可以買口罩股 這樣比較不傷感情

WWIII 05/19 02:05明天口罩崩

ntp915515 05/19 02:11口罩帶到煩了 現在還買口罩股是87嗎

ntp915515 05/19 02:11戴到

bons2 05/19 02:21如果你在疫情區你敢不戴口罩嗎?

gj942l41l4 05/19 02:58低劑量就引發免疫反應??感覺就很奇怪

gj942l41l4 05/19 03:01當然疫苗不是直接打肺炎病毒進去,但如果低劑量就

gj942l41l4 05/19 03:01可以有效產生抗體,早就群體免疫了吧...

gj942l41l4 05/19 03:03不管是減毒疫苗還是非活化疫苗 低劑量都很奇怪

a000000000 05/19 04:18啊他就不是減毒也不是非活化R

ctes940008 05/19 04:35樓上教主

SRadiant 05/19 06:21數據是可信的,臨床一期15人x3組也是OK的,沒有人

SRadiant 05/19 06:21數太少的問題,一期算是成功的,重點在於只是一期

billoma 05/19 06:35理性給推!但炒股不在理性的範疇下

andy70612 05/19 06:40看到雅量 我推了

Whitening 05/19 07:24重點是先炒再說

djbell 05/19 07:26美股都火山爆發了 誰還在乎有沒有效?

yftsai 05/19 07:28疫苗沒那麼簡單啦,即使是萬分之一的副作用都是不可

yftsai 05/19 07:28接受的

yftsai 05/19 07:30進入二期的藥好像也只有10%能上市

elfish123 05/19 08:03難道要等三期成功再買?有些人是不是想先吃貨

kyova 05/19 08:03現在又不是噴回3萬了。跑出一堆勸世或專家來...

kyova 05/19 08:04事實上主要還是法人在操盤,不可能大部分都不懂阿

kyova 05/19 08:04這純粹只是市場信心問題~

kyova 05/19 08:06等後期實驗失敗或解封爆發感染就會殺了嘛,阿如果

kyova 05/19 08:06沒影響那麼多,就會慢慢爬上去了阿...擔心太多

SRadiant 05/19 08:21除非要長抱,不然趕在一期甚至一期前就進場的用意是

SRadiant 05/19 08:21

maxisam 05/19 08:39NBC說45個全都產生抗體

Anyotw 05/19 08:51好的,大噴。我也知道還早,但股價絕對不會等我

kevin540 05/19 09:02

castral 05/19 09:08

goshnash 05/19 09:11高端噴爆

horb 05/19 09:14好的不可思議

gghhbea 05/19 09:30精闢

realbout 05/19 10:01只在乎有沒有撒錢 不在乎基本面

asole 05/19 10:06哈哈 你寫的好有趣!

K0RVER 05/19 10:07這塊綠豆糕砸掉我到嘴的肥肉 啃

lariat 05/19 11:13基亞在之前都樂觀到爆炸

crohns 05/19 18:32也許該公司用了什麼特別的佐劑吧