Re: [新聞] 致死率80%！美研發「人工變異株」　專家

Tosca 發表於 2022/10/19 上午8:58:37

看板Gossiping標題Re: [新聞] 致死率80%！美研發「人工變異株」　專家作者

( )時間Oct 19 08:58:37 2022推噓16 推:17 噓:1 →:10

論文在此
是preprint

https://www.biorxiv.org/content/10.1101/2022.10.13.512134v1.full.pdf

標題
Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1
Omicron

節錄一下重點
We generated chimeric recombinant SARS-CoV-2
encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2
isolate and compared this virus with the naturally circulating Omicron variant. The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor binding motif (RBM), yet unlike
naturally occurring Omicron, efficiently replicates in cell lines and
primary-like distal lung cells. In K18-hACE2 mice, while Omicron
causes mild, non-fatal infection, the Omicron S-carrying virus inflicts
severe disease with a mortality rate of 80%.
This indicates that while the vaccine escape of Omicron is
defined by mutations in S, major determinants of viral pathogenicity
reside outside of S.

翻譯沒有錢拿
阿伯我懶得翻譯了
大家自己去用google翻譯吧

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※ 編輯: Tosca (203.75.79.40 臺灣), 10/19/2022 08:59:01

推

siloin 10/19 09:03300萬謝謝

→

siloin 10/19 09:05疫苗仔會說這是preprint不值得信

推

macocu 10/19 09:06這種研究只會助長更多人研究新疫苗

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